Systemic-oriented clinicians may have an innate aversion to the linear-focused syndrome approach to conceptualizing mental health disorders within individuals. This book offers practical strategies for systemic-oriented clinicians to harmonize the perceived mutual incompatibility between an individual’s dysfunction and commonly used systemic theories and techniques. Users of the book will appreciate the clarification provided on understanding relational problems associated with the onset, progression, and expression of psychiatric symptoms–while incorporating an understanding of parent–child, sibling, extended family, and significant other relationship issues in overall clinical formulation. The book also advances the discussion about relational and cultural features, family systems assessments, family systems interventions, and ethical and legal implications when working with clients and their family members with identified DSM-5 disorders. Each chapter focuses on a specific diagnosis or category of diagnoses from the DSM-5. Seven sections in each chapter guide the reader to explore how best to integrate DSM-5 diagnoses from a systems perspective: DSM-5 and family systems, relational and cultural features, family systems assessments, family systems interventions, ethical and legal implications, case conceptualization, and summary. Each chapter concludes with a summary of the relevant points, providing a focused understanding of the presented disorder and how to address it systemically.