This chapter presents an interaction between the provider and the patient. The patient’s demeanor, tattoos, and piercings had impacted the interaction. The patient’s request for pain medicine changed the provider’s perception of the patient’s complaints. Preconceptions and stereotypes about drug seekers and drug-seeking behaviors affect interpersonal communication and interpersonal relationship development in settings like the emergency department (ED). Verbally aggressive behaviors had impacted the exchange of information. The provider’s willingness to acknowledge the patient’s pain and discuss his or her plans to medicate affects the interaction. Health care providers need to work diligently to keep stereotypes from influencing their perceptions, while at the same time using all the data they can gather to enhance their assessments and decision making. Patients in pain want pain relief, but with drug-seeking patients, especially in urgent care and ED, it can be difficult to assess who needs pain medicine and who does not.