Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. This chapter contains three cases of depressive disorders in adults, including major depressive disorder and dysthymia. These cases illuminate how depression manifests in different people with different backgrounds, including a young Caucasian woman, young biracial man, and a middle-aged woman. While the clients in these cases have symptoms that lead to a DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) diagnosis in the same category, the cases highlight how medical concerns may complicate symptoms, as well as family of origins issues that may exacerbate symptoms. Questions for consideration are also included.