Race, ethnicity, and culture influence client identity and life circumstances. Other factors, such as gender and gender identity, sexual orientation, age, socioeconomic status, religion, and ability may also play into the context of a client’s mental health or personal issues. The four cases in this chapter feature cultural aspects that have a significant role in the treatment and conceptualization by their clinicians. Culturally competent clinicians practice cultural humility and understand that clients’ backgrounds influence the ways in which they view the world and that the clinician’s role must change to accommodate these perspectives.