The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) is the result of the first significant revision of the publication DSM-IV in 1994. With advances in research and clinical applications, modifications were needed to accurately frame client symptom presentation and reflect the changes and advances in science and technology. The collection of cases presented in the book has been compiled from seasoned clinicians that have experienced complex client symptomology. These cases illustrate real world examples of actual clients seen in practice. The details of the cases are organized to provide readers with examples of case conceptualization examples, as well as, diagnostic impressions, conclusions, and treatment recommendations. The book provides a practical and realistic way for students in such mental health professions as clinical psychology, counseling psychology, counseling, and social work to put the new DSM-5 into practice by presenting actual clinical experiences from practitioners. By exploring detailed clinical vignettes, this text offers trainees the opportunity to explore their own ideas on symptom presentation, diagnosis, and treatment planning with a full range of disorders and conditions covered in the DSM-5. The book provides vignettes, but also explores the rationale behind diagnostic criteria and connects diagnostic criteria in the DSM-5 with symptomology in the case. In addition, each case includes a discussion of treatment interventions that is crucial for students in helping professions. These treatment considerations are inclusive of a wide range of evidence-based approaches as appropriate for each case. Techniques/treatment recommendation section will allow the reader to understand how colleagues have conceptualized the case and how specific interventions have been effective in treatment. The goal is for students to enhance their case conceptualization skills and sharpen their ability to understand symptom presentation in light of diagnosing.