This chapter differentiates religion from spirituality and examines the prevalence of both in the African American community. It examines the history of the Black church as well as its overall impact on the African American community. The chapter then elucidates the beginnings of Black Protestant church during slavery followed by its historical and current role in social justice and activism endeavors. It explores Catholicism with a review of some of the differences from Protestant denominations, a historical examination of the African American Catholic Church, and an introduction to Black Catholic theology. Next, the chapter discusses Islam, including the Nation of Islam, and focuses on religion among same gender loving (SGL) African Americans and potential struggles with homonegativity. It concludes by focusing on how religion and spirituality can continue to support the African American community through educational programs, mental and physical health interventions, and support of SGL African Americans.