This chapter focuses on psychosis that is associated with severe mental illness recognized within the schizophrenia spectrum, such as schizophrenia, delusional disorder, schizophreniform disorder, and schizoaffective disorder. Caring for individuals with psychosis can be a challenging yet rewarding aspect of nursing practice. Interviewing and communication have always been primary nursing skills, but these skills are the core of the assessment and care of the client with mental health concerns. In brief psychotic disorder, the psychotic symptoms are sudden and last for at least a day or more, but do not persist beyond a month. Psychotic illness continues to have many misconceptions and myths surrounding it. There remains much fear, stigma, and stereotyping about the concept of psychosis; this is not only perpetuated in the media, but at times even with other health professionals. Nurses are in an excellent position to help educate individuals about these disorders and to help destigmatize these ideas.