This review aimed to identify methodologically sound studies that evaluated the effect of nurse caring on the satisfaction of hospitalized, adult patients. Quantitative studies were located from electronic databases, with a search strategy that focused on titles, key words, index terms, abstracts, and full text published documents on nurse caring or nursing staff caring, patient satisfaction, and hospitalized adults. The initial search identified 2,709 references. Fifty-two full text citations remained for the next step of critical appraisal; 16 documents were included in the final review. Most of the citations were Level VI in a hierarchy of evidence with low quality. Nurse caring protocols need to be developed and linked causally to the outcome of patient satisfaction with hospitalization.