Women with disabilities constitute one of the largest and most disadvantaged populations in the United States. This chapter helps rehabilitation counselors understand the myriad factors that affect the psychological and social health of women with disabilities. After giving some background on the historical roots of the rehabilitation response to women and a description of the demographic and health characteristics of this population, the chapter presents a heuristic, holistic model for understanding the reality of our lives and strategies for helping us achieve optimal health. It first discusses the pivotal construct of self-esteem, followed by social connectedness, its polar opposite abuse and the consequences of disparities stress and depression. The chapter ends with recommendations on strategies that the rehabilitation researchers and practitioners can use to include gender in their examination of individual and program outcomes, and thereby advance the field.