Nonprofit organizations with a social justice mission have historically used social interventions for individual and social change. This chapter talks about nonprofit program leaders and staff with basic competencies in understanding the language and practice of program development and evaluation of social interventions. Emphasizing a social justice approach, it frames program development and evaluation in the context of a “theory of change” and “impact theory” using a logic model, a visual depiction of the change process. Although the chapter focuses on programs, a theory of change framework can be applied to individual and community level interventions with individuals, families, groups, programs, organizations, or communities at a local or global level. It reviews a variety of evaluation methods, such as needs assessments, process and outcome evaluations, and empowerment and culturally competent practice. The chapter also provides some guidelines and recommendations on how to prepare grants and obtain funding.