This book for undergraduate courses teaches students to apply critical thinking skills across all academic disciplines by examining popular pseudoscientific claims through a multidisciplinary lens. It discusses the need for critical thinking, describes pseudoscience, and illustrates some of the common mistakes made in pseudoscientific thinking. Understanding the principles of critical thinking is an essential foundation for making rational decisions, and the basic principles are easy enough to remember and implement when possible. The book also focuses on how the human brain does not process information in a rational, logical fashion and instead is rife with natural biases, and exposes many of the social factors that come into play that prevent one from gaining an unbiased, critical perspective on information. Sensationalist stories gain traction via our confirmation bias, and our cognitive dissonance, not being able to reconcile the complicated version of events with the sensationalist one results in the backfire effect, in which people double down on existing beliefs. The book further discusses alien visitation and abduction and examines two areas where alternative medicine is prevalent—physical health (chiropractic treatment, acupuncture) and mental health (e.g., facilitated communication for autism and sensory integration therapy). Finally, the book takes a look at how religion and culture impact science and vice versa, using the narrative of the “culture wars” surrounding topics such as heliocentrism, the theory of evolution via natural selection, and climate change.