The prison system serves as an institution not only for punishment of crimes committed but as a facility for rehabilitation of offenders. The process of reentry or reintegration may be varied among ex-offenders owing to life circumstances and abilities and is rarely a linear process. Many adult ex-offenders have disabilities that may allow them to apply and qualify for vocational rehabilitation services such as psychiatric disorders, substance abuse and addiction problems, intellectual disabilities, chronic health issues, and dual diagnoses. This chapter presents evidence-based practices for assisting ex-offenders with disabilities from an interdisciplinary and a multiservice provision perspective. Information is presented on barriers to community reintegration including legal concerns, barriers to employment, employers’ hiring practices, and self-imposed barriers. The intent is to present the systematic ways in which ex-offenders with disabilities are unrecognized as vulnerable and marginalized populations that can benefit from an array of services.