Effective practice with immigrants promotes their well-being and should be guided by several considerations that include a multisystem perspective, theoretical perspectives that illuminate their challenges and lived experience, and is based on family assessment and culturally competent skills. In line with this, this chapter focuses on several specific considerations. For one, there is a need to understand immigrant experiences within a multitude of considerations that include psychological, emotional, interpersonal, familial, economic, and government policy factors. Moreover, family systems and ecosystems theories are proposed to illuminate family and intergenerational dynamics, adaptation, and contextual factors that are essential to apply in the process of individualizing what is unique to immigrant clients. Perspectives such intersectionality, oppression, and cultural humility are discussed as essential for social workers to engage and work with immigrants. We emphasize how current perspectives on culturally relevant practice are premised on antioppression values and skills. Finally, we focus on the importance of practitioners having knowledge and skills in the application of the culturagram as a family assessment tool and culturally relevant, antioppression intervention with immigrants.