This chapter discusses the roles, qualifications, and educational opportunities for advanced practice nurses (APRNs) in specialized sleep practice. It provides exemplars of practice models to illustrate available opportunities. APRNs are well-positioned to develop specialized sleep practices, based on their strong preparation in health assessment, health promotion, and management of episodic and chronic health care conditions in a wide variety of populations and the pressing societal need for an increase in sleep specialists. Their expertise in promoting lifestyle change is a particular strength. Possible roles for APRNS are multidimensional and encompass clinical practice, education, advocacy, and research. Creative models of practice are needed and continue to emerge. While there is a growing cadre of APRNs with specialized sleep practices in a variety of settings, there is a need for more systematic opportunities for education in sleep, chronobiology, and sleep disorders in basic nursing education, graduate school, and continuing education (CE).