Depression, once referred to as the common cold of mental health, remains a consistent problem for young adults. Depression and its frequent companion, anxiety, along with many other factors, lead to mental health crises among college students. This chapter provides information for counselors working with college students who present with symptoms of depression and, to some degree, comorbid depression and anxiety. It presents depression and its effect on college students. The chapter presents a case scenario to provide an example of way in which depression and anxiety may combine in presentation. It discusses screening for anxiety and depression as comorbid disorders. The chapter provides techniques for treatment planning and prevention, cultural considerations, and college and university mental health outreach programing related to depression and comorbid anxiety and depression. It highlights several existing outreach programs, provided supplemental programming ideas, and suggested resources for counselors in developing outreach programs on their campuses.