Clinical trials are the engine of progress in the development of new drugs, procedures, and devices for the detection, monitoring, prevention, and treatment of cancer. A well-conceived, carefully designed, and efficiently conducted clinical trial can produce results that change clinical practice, deliver new oncology drugs, interventions, and diagnostics to the marketplace, and expand our understanding of cancer biology. This book presents the latest designs and methods of conducting and analyzing cancer clinical trials in the era of precision medicine with biologic agents including trials investigating the safety and efficacy of targeted therapies, immunotherapies, and combination therapies as well as novel radiation therapy modalities. It provides examples of real-life flaws and real-world examples for how to successfully design, conduct and analyze quality clinical trials and interpret them. With chapters written by oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives. The book provides a comprehensive guide in the design, conduct, monitoring, analysis, and reporting of clinical trials in oncology. It covers various topics such as immunotherapy trials, radiation therapy trials, multi-arm trials, meta-analysis and adaptive design, use of genomics, dose modifications and use of ancillary treatments in investigational studies, establishing surrogate endpoints, practical issues with correlative studies, cost-effectiveness analysis and more. The book is organized into six parts containing 49 chapters. The first part provides background and introduction to oncology clinical trials which includes ethical principles guiding clinical research. The next two parts discusses designing and conducting oncology clinical trials such as phase I, II and III trials; confirmatory clinical trials, noninferiority trials, and quality of life studies. The fourth part describes analyzing results of oncology clinical trials. The fifth part talks about special considerations in oncology clinical trials. The final part discusses about cooperative groups, regulatory, and governing bodies involved in oncology clinical trials.
Your search for all content returned 2 results
Include content types...
Filter results by...
Filter by keyword
- Adaptive Clinical Trials as Topic 1
- adaptive design 1
- agent-based models 1
- Biomarkers 1
- Capital Financing 1
- clinical research administrator 1
- clinical trial 1
- Clinical Trial 1
- Clinical Trials as Topic 1
- Community Health Services 1
- community network analysis 1
- Community Networks 1
- community public health research 1
- concept mapping 1
- confirmatory clinical trial 1
- cooperative group 1
- disease prevention 1
- Equivalence Trial 1
- ethical principles 1
- Ethics, Research 1
- Evaluation Studies as Topic 1
- genomics 1
- Genomics 1
- governing body 1
- Immunotherapy 1
- immunotherapy trial 1
- institutional pilot funding 1
- investigational studies 1
- media analysis 1
- Medical Oncology 1
- Meta-Analysis 1
- meta-analysis 1
- multi-arm trial 1
- noninferiority trial 1
- oncologist 1
- Oncologists 1
- oncology 1
- partnering 1
- Public Health 1
- qualitative methods 1
- Quality of Life 1
- quality of life studies 1
- quantitative methods 1
- radiation therapy trial 1
- Radiotherapy 1
- realist reviews 1
- Research Design 1
- Research Personnel 1
- Spatial Analysis 1
- Systems Analysis 1
Filter by author
- Albert, Steven M. 1
- Alonso, Ariel 1
- Ando, Yuki 1
- Barry, Susan 1
- Barry, William T. 1
- Basch, Ethan 1
- Bassale, Solange 1
- Beaver, Julia A. 1
- Bekele, B. Nebiyou 1
- Blumenthal, Gideon 1
- Bogaerts, Jan 1
- Bottomley, Andrew 1
- Braun, Ada H. 1
- Buddle, Josh 1
- Burdett, Sarah 1
- Burke, Jessica G. 1
- Burzykowski, Tomasz 1
- Buyse, Marc 1
- Callahan, Amy 1
- Carroll-Scott, Amy 1
- Chen, Cong 1
- Chen, Helen 1
- Choi, Woonyoung 1
- Coens, Corneel 1
- Collette, Laurence 1
- Comis, Robert L. 1
- Conaway, Mark R. 1
- Crowley, John 1
- Curriero, Frank 1
- Dahlberg, Suzanne E. 1
- Dave, Gaurav 1
- DeGraffinreid, Cecilia R. 1
- Demolis, Pierre 1
- Dinan, Michaela A. 1
- Dueck, Amylou C. 1
- Evans, Scott R. 1
- Fan, Xiaoyin (Frank) 1
- Filicko-O’Hara, Joanne 1
- Filipenko, Julie 1
- Fisher, David 1
- Francis, Prudence A. 1
- Friedman, Claire F. 1
- Fukuda, Haruhiko 1
- Gaballa, Sameh 1
- Gantz, Christopher 1
- Gillen, Emily M. 1
- Gnanasakthy, Ari 1
- Grady, Christine 1
- Grefenstette, John J. 1
- Groshen, Susan 1
Filter by book / journal title
- Introduction to Public Health, 2nd Edition: Promises and Practices
- Methods for Community Public Health Research: Integrated and Engaged Approaches
- Oncology Clinical Trials, 2nd Edition: Successful Design, Conduct, and Analysis
- Policy and Program Planning for Older Adults and People With Disabilities, 2nd Edition: Practice Realities and Visions
- A Guide to the Standard EMDR Therapy Protocols for Clinicians, Supervisors, and Consultants, 2nd Edition 1
- A Practical Ethics Worktext for Professional Counselors: Applying Decision-Making Models to Case Examples 1
- Acute Leukemia: An Illustrated Guide to Diagnosis and Treatment 1
- Aging in Rural Places: Policies, Programs, and Professional Practice 1
- An Innovative Approach to Career Counseling: Theory and Practical Application 1
- Applied Problem-Solving in Healthcare Management 1
- Behavioral Intervention Research: Designing, Evaluating, and Implementing 1
- Biostatistics for Epidemiology and Public Health Using R 1
- Biostatistics for Oncologists 1
- Cancer Rehabilitation, 2nd Edition: Principles and Practice 1
- Certification in Public Health (CPH) Q&A Exam Review 1
- Community-Oriented Health Services: Practices Across Disciplines 1
- Counseling Individuals With Life-Threatening Illness, 2nd Edition 1
- Death, Dying, and Bereavement: Contemporary Perspectives, Institutions, and Practices 1
- Developing Online Learning in the Helping Professions: Online, Blended, and Hybrid Models 1
- Disability Across the Developmental Lifespan, 2nd Edition: An Introduction for the Helping Professions 1
- Disaster Mental Health Counseling: Responding to Trauma in a Multicultural Context 1
- Effective Counseling and Psychotherapy: An Evidence-Based Approach 1
- Elder Abuse and the Public’s Health 1
- EMDR Therapy for Schizophrenia and Other Psychoses 1
- Eye Movement Desensitization and Reprocessing (EMDR) Scripted Protocols: Basics and Special Situations 1
- Eye Movement Desensitization and Reprocessing (EMDR) Scripted Protocols: Special Populations 1
- Eye Movement Desensitization and Reprocessing EMDR Therapy Scripted Protocols and Summary Sheets: Treating Anxiety, Obsessive-Compulsive, and Mood-Related Conditions 1
- Eye Movement Desensitization and Reprocessing EMDR Therapy Scripted Protocols and Summary Sheets: Treating Trauma- and Stressor-Related Conditions 1
- Fast Facts for the Hospice Nurse, 2nd Edition: A Concise Guide to End-of-Life Care 1
- Foundations in Becoming a Professional Counselor: Advocacy, Social Justice, and Intersectionality 1
- Foundations of School Counseling: Innovation in Professional Practice 1
- Fundamentals of Epidemiology 1
- Gerontechnology: Research, Practice, and Principles in the Field of Technology and Aging 1
- Gynecologic Oncology Handbook, 3rd Edition: An Evidence-Based Clinical Guide 1
- Handbook of Benign Hematology 1
- Handbook of Breast Cancer and Related Breast Disease 1
- Handbook of Gastrointestinal Cancers: Evidence-Based Treatment and Multidisciplinary Patient Care 1
- Handbook of Geriatric Oncology: Practical Guide to Caring for the Older Cancer Patient 1
- Handbook of Hematologic Malignancies, 2nd Edition 1
- Handbook of Lung Cancer and Other Thoracic Malignancies 1
- Handbook of Minority Aging 1
- Handbook of Prostate Cancer and Other Genitourinary Malignancies 1
- Handbook of Theories of Aging, 3rd Edition 1
- Healing the Fractured Child: Diagnosis and Treatment of Youth With Dissociation 1
- Health Communication Fundamentals: Planning, Implementation, and Evaluation in Public Health 1
- Health Equity: A Solutions-Focused Approach 1
- Health Literacy Among Older Adults 1
- Health Policy and Analysis, 2nd Edition: Framework and Tools for Success 1
- Health Services Research and Analytics Using Excel® 1
- Health, Illness, and Optimal Aging, 3rd Edition: Biological and Psychosocial Perspectives 1
- Homeless Older Populations: A Practical Guide for the Interdisciplinary Care Team 1
- Infectious Disease Epidemiology: An Introduction 1
- Integrating EMDR Into Your Practice 1
- Introduction to Group Counseling: A Culturally Sustaining and Inclusive Framework 1
- Introduction to Public Health, 2nd Edition: Promises and Practices
- Methods for Community Public Health Research: Integrated and Engaged Approaches
- Oncology Clinical Trials, 2nd Edition: Successful Design, Conduct, and Analysis
- Policy and Program Planning for Older Adults and People With Disabilities, 2nd Edition: Practice Realities and Visions
Filter by subject
- Medical Oncology
- Medicine 1
- Nursing
0
- Administration, Management, and Leadership 0
- Advanced Practice 0
- Clinical Nursing 0
- Critical Care, Acute Care, and Emergency 0
- Geriatrics and Gerontology 0
- Doctor of Nursing Practice 0
- Nursing Education 0
- Professional Issues and Trends 0
- Research, Theory, and Measurement 0
- Undergraduate Nursing 0
- Special Topics 0
- Exam Prep and Study Tools 0
- Physician Assistant 0
- Behavioral Sciences 1
- Health Sciences 1
Your search for all content returned 2 results
- Book
This book introduces emerging research methods that will assist community health researchers interested in effectively addressing the complex health issues faced by communities today. It also introduces readers to several research methods particularly appropriate for addressing the context of health issues, translating research into action, and engaging community and relevant stakeholders. Use of these methods will lead to advancements in the field of community health and ultimately to improvements in community health. The book illustrates how community health researchers must move beyond the rigid distinction between qualitative and quantitative methods to adopt new integrated research methods to understand health as a community system. Within the discipline of public health, community health is an important and evolving subdiscipline that specifically emphasizes disease prevention and early intervention for members of a given community. The book includes spatial analysis, agent-based models, community-network analysis and realist reviews and addresses system dynamics, concept mapping, visual voices and media analysis. Integration of qualitative and quantitative data is key to generating unique insights into the mechanisms linking complex community health issues and to providing critical guidance regarding the pathways toward effective intervention and prevention. Institutional pilot funding, often available to researchers based at academic institutions, is a good option to garner support for innovative community health research projects. Partnering with other researchers and community members to learn and apply new and innovative research methods is a necessary steps toward more effectively addressing and improving the health of communities.