This book is intended for public health practitioners, researchers, students, and other professionals who work in rural settings or who are interested in learning more about the unique aspects of public health in rural areas. It first presents some of the best-established challenges in rural public health, including medical care barriers, workforce issues, and ethics, followed by some of the specific rural-focused solutions that have been developed through faith-based initiatives and integrated care efforts. By recognizing the socioeconomic and cultural factors unique to rural areas as not only contributing to health disparities (e.g., higher smoking rates) but also as providing avenues for addressing them (e.g., faith-based initiatives), rural public health practitioners can begin to make long-needed progress in protecting the health of one fifth of the U.S. population. The book then discusses both the scope and state of prevention for specific health issues in rural settings, including mental health, substance abuse, heart disease, obesity, diabetes, HIV, environmental health, minority health, migrant farmworker health, and elderly health. The book then concludes with a summary of the future directions in rural public health to serve as a road map for moving forward.