Case Report
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Abstract
Introduction
Cisplatin is used to treat cancers that affect women of childbearing age and those that may breastfeed. Prior literature regarding the duration of cisplatin excretion in human milk is sparse and suggests complete clearance days after initial administration.
Method
We present the case of a postpartum woman who received three doses of weekly cisplatin for cervical cancer. Platinum levels were measured in expressed milk for several months after cisplatin administration.
Results
Levels of the parent element platinum were detected 159 days (over 22 weeks) followingadministration. These results demonstrate persistence of detectable platinum levels for a muchlonger period than previously reported.
Conclusion
This case report is the first to follow platinum levels in expressed milk after multiplepostpartum cisplatin doses. Our results demonstrate a biphasic elimination with detectionspanning several months after cessation of treatment. Women should be advised to abstainfrom breastfeeding until long after completion of cisplatin therapy.
Article usage
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